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高血压是一种全球性流行的慢性疾病，给人类健康带来了重大威胁。随着对内源性多肽研究的深入，这类生物活性分子在高血压的预防和治疗方面逐渐受到关注。内源性多肽不仅具有调节血压的潜力，还在心血管健康中发挥重要作用。尽管已有研究表明内源性多肽在高血压防治中的积极作用，但目前仍存在临床应用不足、机制尚不明确等问题。文章通过综述内源性多肽的最新研究进展，分析其在高血压防治中的应用现状与临床评价，并基于蛋白质组学检测技术探讨内源性多肽发掘在高血压防治中的临床应用。通过对这些研究成果的归纳和分析，为内源性多肽发掘在高血压防治中的进一步应用提供新的思路和方向。
Abstract：Hypertension is a globally prevalent chronic disease that poses a significant threat to human health. With the deepening research on endogenous peptides, these bioactive molecules have gradually attracted attention in the prevention and treatment of hypertension. Endogenous peptides not only have the potential to regulate blood pressure but also play an important role in cardiovascular health. Although studies have shown the positive effects of endogenous peptides in the prevention and treatment of hypertension, there are still issues such as insufficient clinical application and unclear mechanisms. This article reviews the latest research progress of endogenous peptides, analyzes their application status and clinical evaluation in the prevention and treatment of hypertension, and explores the clinical application of endogenous peptide exploration in hypertension prevention and treatment based on proteomics detection technology. Through the summarization and analysis of these research results, this paper aims to provide new ideas and directions for the further application of endogenous peptide exploration in the prevention and treatment of hypertension.
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基本信息:
DOI：10.20219/j.cnki.2095-6584.2025.06.024
中图分类号:R544.1
引用信息:
[1]刘姝含,沈晨,张强翔,等.内源性多肽发掘在高血压防治中的临床应用[J].襄阳职业技术学院学报,2025,24(06):107-112.DOI:10.20219/j.cnki.2095-6584.2025.06.024.
基金信息:
襄阳市医疗卫生领域指导性计划项目“‘精准医疗’背景下基于基因数字化血小板供者库的建立及其临床应用”（2022BBS005204）; 襄阳职业技术学院青年基金项目“基于血清多肽组学分析挖掘降血压生物活性肽及其机制研究”（XYZY2023GB17）
2025-12-20
2025-12-20